Delix

introduction

The drug known under the trade name Delix® contains the active ingredient ramipril.

Ramipril itself becomes a group of ACE inhibitors (Angiotensin converting enzyme inhibitors) and mainly used to treat high blood pressure (arterial hypertension) used. This enzyme is used to convert the inactive form of a blood pressure-regulating messenger substance into its active form.

For this reason, ramipril can lower the blood pressure by inhibiting the angiotensin converting enzyme.

In addition to this main reason for prescribing, Delix® can also be used for the therapy of existing heart failure or for the prevention of a heart attack.

application areas

Delix® and others containing ramipril Medication (for example Ramilich) can be used in two different ways.

Delix unfolds as a so-called monopreparation® its effect without further aids, as a combination preparation it becomes with others Antihypertensive administered in combination. Typical medications that go in along with Delix® are used among other things Diuretics, so those drugs that increase on the Kidney function and Urine output affect or Calcium channel blockers.

Calcium channel blockers generally lower the muscle tone of vascular smooth muscles and thereby effectively reduce the Blood pressure.

The effect of a combination therapy is compared to the exclusive use of Delix® usually more effective.

In the successful therapy of heart failure, Delix® one of, if not the, most promising drugs.

Furthermore one writes Delix® and other drugs containing ramipril have a preventive effect on the development of a heart attack.

For this reason, it is often taken prophylactically by high-risk patients or by patients who have already suffered a heart attack.

How does Delix® work?

The falls Blood pressure in the human body falls below a normal value, this is what happens with the kidney cells Renin enzyme released. This enzyme is able to set the most important blood pressure-regulating cascade in motion.

Renin activates a second first enzyme (Angiotensin I), which is converted into the active form via the so-called angiotensin converting enzyme Angiotensin II is converted. Angiotensin II can now ensure that the blood pressure increases through various processes.

Delix®and other Ramipril- Medicines containing them intervene in this enzyme cascade by preventing the activation of angiotensin I to angiotensin II by inhibiting the angiotensin converting enzyme.

The result is that the blood pressure via the system just described (renin-angiotensin-aldosterone system, in short: RAAS) can no longer be increased.

In people with high blood pressure, this can result in lower values ​​and a decrease in the stress on the vessels and the Heart be achieved.

Side effects

While taking Delix®or other drugs containing ramipril, a number of side effects may occur.

Some patients suffer from severe Skin reactionsFor example, they develop a widespread skin rash (exanthema) or hives.
It can also be through Delix® water retention in the tissue.

Severe skin reactions with allergy-like extent however, are extremely rarely observed. They usually only occur in people who have been treated under a real one allergy against the active ingredient Ramipril or have other ingredients in the drug.

Furthermore arise during the Delix®- Ingestion in rare cases respiratory problems. It can cause dryness to cough, Sore throat and hoarseness come.

A few patients report the occurrence of Asthma attacks while being treated with Delix®.

Since the effect of Delix® and other ramipril-containing drugs are effective in lowering blood pressure, it may also Circulatory problems and dizziness come.

Also the increased occurrence of a headache cannot be ruled out.

During the pregnancy may Delix® should never be taken, as the active ingredient ramipril can lead to severe growth and bone formation disorders in the unborn child. In the worst case scenario, Delix causes® even one Termination of pregnancy.

Interactions

Delix® and other drugs containing ramipril exert a strongly exacerbating effect on the antihypertensive effect of the hormone insulin out. In addition, using Delix® the intensity of antidiabetic drugs can be increased immensely. In this context, it can lead to circulatory problems if taken at the same time dizziness come.

In addition, through the use of Delix® interfered with the natural water and electrolyte balance.

This usually leads to a reduced and slowed elimination of electrolytes, which for this reason accumulate in particularly high concentrations in the organism.

This fact can have an impact on treatment with so-called potassium-sparing Diuretics (serve to increase kidney excretion) to have. When taking Delix at the same time® and potassium-sparing diuretics should therefore pay particular attention to the Potassium levels be placed.

Both too low and too high a potassium concentration in the body can lead to immense heart problems and even heart failure.

Contraindications

Because Delix® exerts a strong influence on the vascular tone and blood pressure, it may not be taken unconditionally by some patient groups.

There is a particular danger with people who have a Aortas- and or Mitral valve stenosis (Narrowing the heart valves) Suffer. Also used by patients with other diseases that adversely affect blood flow from the left ventricle effect, Delix® never be taken.

In primary hyperaldosterism, the body consumes too much Aldosterone produced. In patients who have this condition (also known as Conn syndrome) should suffer Delix® not be applied.

This fact is due to the fact that the drug is due to the high Aldosterone Concentration has no effect on blood pressure.

In people with impaired kidney function (impaired kidney function) can while you are taking Delix® a drop in blood pressure beyond the desired level occurs. This is an initial indication of further deterioration in kidney function caused by the use of Delix® can be triggered.

After a Tkidney transplant may Delix® or other drugs containing ramipril are not prescribed. The most common reason against treating high blood pressure with Delix® speaks is hypersensitivity to the active ingredient or other ingredients of the drug.