ASS 100
Synonyms of ASS 100
Acetylsalicylic acid, ASA, Aspirin®
Introduction / definition
Acetylsalicylic acid is used in the low dose of 100 mg to inhibit blood clotting. It ensures that the thrombocytes, i.e. blood platelets, can no longer adhere and clump together, as would be the case with normal blood clotting. The ASA 100 is therefore well suited therapeutically to prevent a blood clot from forming, as well as for the preventive treatment of heart attacks and strokes.
Mode of action of ASA
ASS 100 has an inhibiting effect on the physiological process of the Blood clottinglocated in primary and secondary hemostasis can be divided.
The primary hemostasis takes care of the Hemostasis and the secondary for the actual clotting of the blood. The acetylsalicylic acid unfolds its effect over a Inhibition of hemostasis.
If there is a vascular injury, the tissue around the wound contracts first. Blood platelets now bind via various glycoprotein receptors (Platelets) on exposed collagen fibers at the site of the injury. About this so-called "adhesion“The platelets are activated and release various mediators, including calcium, serotonin, ADP and thromboxane A2.
Even more platelets are attracted and the otherwise flat platelets change in shape. The now spherical and prickly state allows them one slight clumping together. This is how a loose wound closurewho through the secondary hemostasis eventually becomes consolidated.
Acetylsalicylic acid is irreversible Cyclooxygenase inhibitors (COX inhibitors). The COX is located in the platelets and is responsible for the production of thromboxane A2 from arachidonic acid. If the COX is inhibited, can no thromboxane be distributed and its effect, the Constriction of the tissue and clumping of platelets, no longer run properly. Inhibited
Cyclooxygenase cannot use the Platelets be replicated. The anticoagulant effect lasts until enough new platelets were created which again contain a fully functioning cyclooxygenase. The Lifetime of platelets is approx 7-12 days, as long as the effect of ASS 100 lasts.
Application of ASS 100
ASS 100 is does not require a prescription and can be purchased from the pharmacy in tablet form. The intake takes place after eating together with a glass of water. Care must be taken with the tablet to be swallowed whole if possible. The exception is the acute heart attack dar: here should the first chewed tablet swallowed become.
application
In patients with an unstable Angina pectoris ("Chest tightness", triggered by circulatory disorders in the Coronary arteries) and an acute heart attack, the recommended daily dose is 100 mg. To prevent another heart attack, a dose of 3x 100 mg daily administered.
To Operations and vascular surgical examinations a dose of 1x 100mg per day is provided, also for the prevention of a stroke. In general, ASS 100 should be used for a long-term therapy may be used, but the doctor in charge will determine the exact duration.
Does ASS 100 help against headaches?
ASS 100 is not effective against jokes. For the pain relieving (analgesic) component of ASA, higher doses (ASA 500) are required. However, if the headache is caused by a circulatory disorder, ASS 100 can already relieve this pain. These headaches can occur when a blood vessel constricts (stenosis) or when the blood is too thick. Thanks to the anticoagulant properties of ASS 100, headaches can be alleviated.
Side effects
Symptoms of the gastrointestinal tract are among the common side effects of ASS 100
- stomach pain
- nausea
- diarrhea
- Vomit
- heartburn
Occasionally it can be too
- Bleeding or ulcer in the gastrointestinal tract (hidden bleeding may show up as iron deficiency anemia (anemia).
- Black chair
- allergic reaction on the skin
Rare side effects are
- severe hypersensitivity reactions (skin rash)
- Facial swelling
- Shortness of breath
- Epistaxis
- Bleeding gums and skin may occur
cerebral haemorrhage can occur very rarely.
Read more on the topic: What are the causes of a cerebral hemorrhage
Can stomach pain occur?
Stomach pains should not occur with long-term intake of ASA 100. These stomach pains, which indicate an inflammation of the stomach lining (gastritis) or a stomach ulcer (gastric ulcer), usually only occur during the ingestion of ASA 500. This is due to an increased production of stomach acid. These symptoms can be alleviated by additionally taking a proton pump inhibitor such as omeprazole or pantoprazole. Due to the risk of ulcer formation, ASA 500, unlike ASA 100, should not be used over a longer period of time. If your stomach pain persists, you should definitely consult a doctor. The presence of a stomach ulcer can lead to a gastric perforation and thus to heavy internal bleeding. The gastric ulcer can only be secured with a gastroscopy, but it can also be treated with proton pump inhibitors.
Contraindications for ASA 100
ASS 100 should not taken be when a known allergy compared to the active ingredient. Also with existing ones Gastrointestinal ulcers, a reinforced Bleeding tendency, severe liver and Kidney dysfunction and one Ingestion of more than 15mg Methotrexate (a Cytostatic to treat malignant Tumors) per week.
In the pregnancy and breastfeeding higher doses ASS 100 (> 150 mg) to avoid. In the first 6 months of pregnancy, intake should definitely be discussed with the attending physician.
A strictly controlled treatment should take place if other Painkiller allergies are known at chronic respiratory diseases, with additional coumarin therapy (e.g. with Marcumar®), Liver and / or kidney dysfunction and at upcoming operations (Increased risk of bleeding).
ASS 100 and desire to have children
The intake of ASS 100 has no influence on conception. ASA can therefore be used safely even if you want to have children. There is a widespread opinion on the Internet that ASA promotes conception. However, there are no studies that prove this. It is certain, however, that ASS 100 has no negative effects on the desire to have children.
ASS 100 during pregnancy
ASS 100 is harmless during pregnancy. ASA is used in a low dose to inhibit blood clotting. This is necessary if there is an increased tendency to form blood clots (thrombosis) or after a heart attack. It is also used in angina pectoris and coronary heart disease (CHD). In contrast, in higher doses (ASA 500), ASA has a pain-relieving (analgesic), fever-lowering (antipyretic) and anti-inflammatory (anti-inflammatory) effect.
The ASS 500 should not be taken in the last trimester of pregnancy. High doses of ASA lead to premature closure of the ductus arteriosus botalli, the connection between the pulmonary artery and the aorta (main artery). This leads to pulmonary hypertension (high lung pressure) in the unborn child and affects the pumping capacity of the heart. There are studies that show that ASA 100 reduces the risk of preeclampsia during pregnancy and that there is less growth retardation and intrauterine fetal death. This even suggests a beneficial effect during pregnancy. When taking ASA, the ductus arteriosus botalli should be examined regularly by the gynecologist in the last trimester using ultrasound. A few days before the birth, the ASA should be discontinued because of the increased tendency to bleed during the birth.
Read more on the subject at: Aspirin in pregnancy
Aspirin® and alcohol
When taking Aspirin® and alcohol can it to unwanted side effects come, which can sometimes be associated with dangerous consequences for the person concerned. Especially the danger of Stomach ulcer and Bleeding in the stomach, known side effects of taking aspirin, can be exacerbated by the simultaneous consumption of alcohol.
Irritations of the Gastric mucosa, Gastric bleeding and stomach ulcers can be noticeable by a variety of typical symptoms. Gastric bleeding is characteristic of this jet black colored chairs and bloody or coffee grounds Vomit hand in hand. Excessive bleeding can result in significant blood loss and associated symptoms. Chronic gastric ulcers can lead to changes in the gastric outlet and thus Digestive problems and induce vomiting. Stinging are also typical stomach pain which occur especially after eating.
Read more on this topic at: Aspirin® and alcohol
