Drug

Imipramine

Use machines and ability to drive

General

Imipramine belongs to the group of tricyclic antidepressants and can be used to treat depressive states or chronic pain.

Imipramine belongs to a group of medicines called tricyclic antidepressants. Imipramine is mostly used in salt form as so-called imipramine hydrochloride.
Imipramine requires a prescription and may therefore only be taken as indicated by a doctor.

Potency

Imipramine is available as Dragées and also as Film-coated tablets available and these contain either 10 mg, 25 mg or 100 mg imipramine hydrochloride. The doctor decides which dosage should be selected individually for the patient.

application areas

Imipramine can be used for the following diseases or symptoms:

depressive illnesses
long-term pain management
Treatment of bed-wetting and night terrors

Contraindications

Not to be applied Imipramine is allowed in one of the following cases:

Hypersensitivity to any of the ingredients
acute alcohol poisoning
acute intoxication poisoning
acute pain medication poisoning
acute psychotropic intoxication
more acute Urinary retention
acute delirium
untreated increased pressure in the eye
Enlargement of the prostate
Narrowing of the gastric outlet
Intestinal paralysis
Treatment with other medicines for depression
Recovery period after one Heart attack

Only under strict medical supervision and control Imipramine may be used if the following information applies or applies to the patient:

severe liver damage
severe kidney damage
increased propensity for convulsions
Blood formation disorders
Adrenal market tumors
Previous damage to the heart

Imipramine in children

Imipramine should be used to treat children and adolescents under 18 years of age not applied as in studies in this age group no therapeutic benefit could be shown through this type of therapy.
Additionally come the serious possible side effects, such as on Cardiovascular system to weigh even heavier in children.
With regard to long-term use in children and adolescents in terms of growth, maturation, intellectual development and behavioral development, no data are available to date.
In children under 5 years of age, therapy with imipramine should not be given for indications for imipramine such as bedwetting and night terrors, as there is no empirical data.

pregnancy

Treatment with imipramine during pregnancy revealed so far no observation of teratogenic effects. Nevertheless, imipramine should be used especially in the first trimester of pregnancy only if there is a compelling medical indication be applied.
If use in the last trimester of pregnancy is unavoidable, the newborn should be monitored during the first month of life for the withdrawal symptoms of colic, cyanosis and agitation, which in newborns is difficult to distinguish from other causes shortly after birth.

Lactation

If breast-feeding is used during treatment with imipramine, the child should be monitored for signs of imipramine effect and weaned at the first sign.

Use machines and ability to drive

Taking imipramine may reduce your ability to drive and operate heavy machinery. This applies in particular to the start of treatment, change of preparation, parallel medication with other drugs.

For this reason, we strongly advise against using electrical tools, machines and vehicles during this period!

Interactions

The following interactions are known for imipramine:

enhanced effect of alcohol when taken at the same time
increased imipramine effect when taken at the same time Fluoxetine or fluvoxamine
enhanced effect of vasoconstricting agents when taken at the same time
severe side effects when taken at the same time other antidepressants (14 days break!)
Attenuation of Antihypertensive drugs when taken at the same time
enhanced effect of Antiarrhythmics when taken at the same time
increased imipramine effect when taken at the same time Neuroleptics
increased imipramine effect when taken at the same time Cimetidine
Reduced effectiveness of imipramine when taking Anti-epileptic drugs
Reduced effectiveness of imipramine Nicotine consumption
Reduced effectiveness of imipramine when taking the Birth control pills
Reinforcement of the effect anticoagulant drugs while taking imipramine